GLP-1 Protein Calculator
Calculate protein targets for muscle preservation during GLP-1 therapy. Based on STEP trial data and muscle protein synthesis research.
GLP-1 medications like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) are highly effective for weight loss — but STEP trial data suggests that 25–40% of weight lost can be lean mass, not fat. Preserving muscle matters for long-term metabolic health, strength, and how your body looks at goal weight.
Protein is the primary nutritional lever. Higher intake combined with resistance training is the evidence-backed strategy to shift the fat-to-muscle loss ratio in your favor. Muscle protein synthesis (MPS) requires a minimum threshold of roughly 20–40g of protein per meal to trigger a full anabolic response — spreading intake across meals matters as much as the daily total.
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